Research is our passion

The working group

Translational Cancer Research

Head: ao. Univ.-Prof. Dr. Heinz Zwierzina

In recent years, the importance of the immediate biological environment of a malignant tumor has become increasingly apparent in tumor research. This tumor environment, also known as a tumor metromilieu, affects not only the development of the tumor (carcinogenesis), but also the behavior of immune cells against the malignant tumor cells.

These effects have not been or have not been adequately considered in previous preclinical models for the development and testing of antitumoral substances. Our working group is concerned with the development of preclinical models which are designed to represent the tumor and its environment as precisely as possible. For this purpose, the principle of 3D cell culture is applied using the "hanging-drop" method. In this project it is attempted to cultivate so-called micro-tissues, which consist of cells of a tumor cell line (for example, lung carcinoma) and cells of the tumor metromelie (fibroblasts, endothelial cells, immune cells) and to determine their usefulness for the testing of antitumoral substances. The aim of another project of our group is to obtain tissue material from cancer patients and to process it so that it can be used in the 3D cell culture for the generation of microtissues. Subsequently, assays are then to be developed in order to predict which medications the cancer cells of the patient are responding to. A third project deals with the development of an "immunoscores" for the non-small-cell lung carcinoma.

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The Tyrolean Cancer Research Institute has the goal to develope new cancer therapy concepts and to get them to clinical use. This ambitious achievement underlines the creative optimism wich inspires the whole initiative.
Head: ao. Univ.-Prof. Dr. Heinz Zwierzina

Publications

Steiner N, Borjan B, Hajek R, Jöhrer K, Göbel G, Willenbacher W, Kern J, Gunsilius E, Untergasser G. Oncotarget 2017, doi: 10.18632/oncotarget.17353

Koeck S, Kern J, Zwierzina M, Gamerith G, Lorenz E, Sopper S, Zwierzina H, Amann A. Oncoimmunology 2017, 6(6):e1323617

Amann A, Zwierzina M, Koeck S, Gamerith G, Pechriggl E, Huber JM, Lorenz E, Kelm JM, Hilbe W, Zwierzina H, Kern J. Sci Rep. 2017, 7(1):2963

Seeber A, Gastl G, Ensinger C, Spizzo G, Willenbacher W, Kocher F, Leitner C, Willenbacher E, Amann A, Steiner N, Eisterer W, Voss A, Russell K, Zwierzina H. Genes Cancer 2016, 7;(9-10):301-308

Huber JM, Amann A, Koeck S, Lorenz E, Kelm JM, Obexer P, Zwierzina H, Gamerith G. J Cancer Res Clin Oncol 2016, 142(9):1955-66

Koeck S, Zwierzina M, Huber JM, Bitsche M, Lorenz E, Gamerith G, Dudas J, Kelm JM, Zwierzina H, Amann A. Immunobiology 2016, 221(5):604-17

Borjan B, Steiner N, Karbon S, Kern J, Francesch A, Hermann M, Willenbacher W, Gunsilius E, Untergasser G. BMC Cancer 2015, 15:738

Steiner N, Ribatti D, Willenbacher W, Jöhrer K, Kern J, Marinaccio C, Aracil M, García-Fernández LF, Gastl G, Untergasser G, Gunsilius E. Oncotarget 2015, 6(10):8200-9

Thangavadivel S, Zelle-Rieser C, Olivier A, Postert B, Untergasser G, Kern J, Brunner A, Gunsilius E, Biedermann R, Hajek R, Pour L, Willenbacher W, Greil R, Jöhrer K. Oncotarget 2016, 7(48):78605-78618

Schimke MM, Stigler R, Wu X, Waag T, Buschmann P, Kern J, Untergasser G, Rasse M, Steinmüller-Nethl D, Krueger A, Lepperdinger G. Nanomedicine 2016, (3):823-33

Pircher A, Jöhrer K, Kocher F, Steiner N, Graziadei I, Heidegger I, Pichler R, Leonhartsberger N, Kremser C, Kern J, Untergasser G, Gunsilius E, Hilbe W. Oncotarget 2016, 7(15):20109-23