The immune system is an effective control system in the detection and elimination of malignant cells (immunosurveillance of tumors). In the phase of tumor progression, however, this mechanism fails. The tumor immunology team is therefore concerned with the interaction between the immune system and the tumor and examines the changes caused by cancer and tumor therapy. Based on these findings, different approaches are developed to eliminate negative regulators and to strengthen effector functions against the tumor.
ENEST1st study: Pharmacokinetics and Immune monitoring In patients with early chronic phase CML treated with frontline Nilotinib. (Novartis)
ALLIVE study: Immune monitoring of AML and MDS patients receiving allogeneic stem cell transplantation. (GWD_TUD)
Oncotyrol: Identification and targeting of ovarian cancer stem cells. (FFG) Improvement of tumor immune therapy by adoptive cell transfer of cblb-deficient hyperreactive immune cells. (FWF)
Intracellular routine assay for detection of TKI-efficacy in CML patients. (ÖNB) Assessing the immune status and its relevance in non-small cell lung cancer patients. Genetically engineered immune cells expressing chimeric antigen receptor targeting HER2neu as tool to break tumor tolerance.
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